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BioActinide Chemistry Group @ Berkeley

Publications & Patents

We publish our research in peer-reviewed journals and patent our discoveries at Berkeley Lab and UC Berkeley.

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Google Patents

2022

  1. Pallares RM, Abergel RJ “Development of radiopharmaceuticals for targeted alpha therapy: Where do we stand?” Front. Med. 2022, 9:1020188. DOI: 110.3389/fmed.2022.1020188. Link
  2. Pallares RM, An DD, Hebert S, Loguinov A, Proctor M, Villalobos JA, Bjornstad KA, Rosen CJ, Vulpe C, Abergel RJ “Identifying Toxicity Mechanisms Associated with Early Lanthanide Exposure through Multidimensional Genome-Wide Screening” ACS Omega 2022, 7, 34412-34419. DOI: 10.1021/acsomega.2c04045. Link
  3. Pallares RM, Flick M, Shield KM, Bailey TA, Velappan N, Lillo AM, Abergel RJ “Development of an Actinium-225 Radioimmunoconjugate for Targeted Alpha Therapy against SARS-CoV-2” New J. Chem. 2022, 46, 15795-15798. DOI: 10.1039/D2NJ02617A. Link
  4. Bailey TA, Wacker JN, An DD, Carter KP, Davis RC, Mocko V, Larrabee J, Shield KM, Lam MN, Booth CH, Abergel RJ “Evaluation of 134Ce as a PET imaging surrogate for antibody drug conjugates incorporating 225Ac” Nucl. Med. Biol. 2022, 110-111, 28-36. DOI: 10.1016/j.nucmedbio.2022.04.007. Link
  5. Pallares RM, Jarvis E, An DD, Wu CH, Chang PY, Abergel RJ “Toxicogenomic assessment of organ-specific responses following plutonium internal contamination” Environ. Adv. 2022, 8, 100245. DOI: 10.1016/j.envadv.2022.100245. Link
  6. Carter KP, Wacker JN, Smith KF, Deblonde GJP, Moreau LM, Rees JA, Booth CH, Abergel RJ “In Situ Beam Reduction of PuIV and BkIV as a Route to Trivalent Transuranic Coordination Complexes with Hydroxypyridinone Chelators” J. Synchrotron Radiat. 2022, 29 (2), 315-322. DOI: 10.1107/S1600577522000200. Link
  7. Abergel RJ, Aris J, Bolch WE, Dewji SA, Golden A, Hooper DA, Margot DD, Menker CG, Paunesku T, Schaue D, Woloschak GE “The Enduring Legacy of Marie Curie: Impacts of Radium in 21st Century Radiological and Medical Sciences” Int. J. Radiat. Biol. 2022, 98 (3), 267-275. DOI: 10.1080/09553002.2022.2027542. Link
  8. Pallares RM, An DD, Hebert S, Faulkner D, Loguinov A, Proctor M, Villalobos JA, Bjornstad KA, Rosen CJ, Vulpe C, Abergel RJ “Delineating Toxicity Mechanisms Associated with MRI Contrast Enhancement through a Multidimensional Toxicogenomic Profiling of Gadolinium” Mol. Omics. 2022, 18, 237-248. DOI: 10.1039/D1MO00267H. Link
  9. Pallares RM, Charrier M, Tejedor-Sanz S, Li D, Ashby PD, Ajo-Franklin CM, Ralston CY, Abergel RJ “Precision Engineering of 2D Protein Layers as Chelating Biogenic Scaffolds for Selective Recovery of Rare-Earth Elements” J. Am. Chem. Soc. 2022, 144 (2), 854-861. DOI: 10.1021/jacs.1c10802. Link

2021

  1. Pallares RM, An DD, Hebert S, Faulkner D, Loguinov A, Proctor M, Villalobos JA, Bjornstad KA, Rosen CJ, Vulpe C, Abergel RJ “Multidimensional genome-wide screening in yeast provides mechanistic insights into europium toxicity” Metallomics 2021, 13 (12), mfab061. DOI: 10.1093/mtomcs/mfab061. Link
  2. Alrich K, Livshits M, Stromberg L, Janicke MT, Lam MN, Stein BW, Wagner G, Abergel RJ, Mukundan H, Kozimor SA, Lilley LM ”ThIV–Desferrioxamine: Characterization of a Fluorescent Bacterial Probe” Dalton Trans. 2021, 50 (42), 15310-15320. DOI: 10.1039/D1DT02177J. Link
  3. Pallares RM, Hebert S, Sturzbecher-Hoehne M, Abergel RJ “Chelator-assisted high performance liquid chromatographic separation of trivalent lanthanides and actinides” New J. Chem. 2021, 45, 14364-14368. DOI: 10.1039/D1NJ01966J. Link
  4. Pallares RM, Faulkner D, An DD, Hebert S, Loguinov A, Proctor M, Villalobos JA, Bjornstad KA, Rosen CJ, Vulpe C, Abergel RJ (2021). Genome-wide toxicogenomic study of the lanthanides sheds light on the selective toxicity mechanisms associated with critical materials. Proc. Natl. Acad. Sci. 2021, 118 (18). DOI: 10.1073/pnas.2025952118. Link
  5. Bessen NP, Popov IA, Heathman CR, Grimes TS, Zalupski PR, Moreau LM, Smith KF, Booth CH, Abergel RJ, Batista ER, Yang P, Shafer JC (2021). Complexation of Lanthanides and Heavy Actinides with Aqueous Sulfur-Donating Ligands. Inorg. Chem. 2021, 60 (9), 6125-6134. DOI: 10.1021/acs.inorgchem.1c00257. Link
  6. Arnedo-Sanchez L, Smith KF, Deblonde GJP, Carter KP, Moreau LM, Rees JA, Tratnjek T, Booth CH, Abergel RJ “Combining the Best of Two Chelating Titans: A Hydroxypyridinone‐Decorated Macrocyclic Ligand for Efficient and Concomitant Complexation and Sensitized Luminescence of f‐Elements” ChemPlusChem 2021, 86 (3), 483-491. DOI: 10.1002/cplu.202100083. Link
  7. Pallares RM, An DD, Deblonde GJP, Kullgren B, Gauny SS, Jarvis EE, Abergel RJ “Efficient discrimination of transplutonium actinides by in vivo models” Chem. Sci.2021, 12 (14), 5295-5301. DOI: 10.1039/D0SC06610A. Link
  8. Pallares RM, Carter KP, Faulkner D, Abergel RJ “Macromolecular crystallography for f-element complex characterization” Meth. Enzymol. 2021, 651, 139-155. DOI: 10.1016/bs.mie.2021.01.014. Link
  9. Mueller A, Deblonde GJP, Ercius P, Zeltmann SE, Abergel RJ, Minor AM “Probing electronic structure in berkelium and californium via an electron microscopy nanosampling approach” Nat. Comm. 2021, 12 (1), 1-6. DOI: 10.1038/s41467-021-21189-1. Link
  10. Pallares RM, Abergel RJ “Diagnostic, Prognostic and Therapeutic Use of Radiopharmaceuticals in the Context of SARS-CoV-2” ACS Pharm. Trans. Sci. 2021, 4 (1), 1-7. DOI: 10.1021/acsptsci.0c00186. Link
  11. Carter KP, Shield KM, Smith KF, Jones ZR, Wacker JN, Arnedo-Sanchez L, Mattox TM, Moreau LM, Knope KE, Kozimor SA, Booth CH, Abergel RJ “Structural and Spectroscopic Characterization of an Einsteinium Complex” Nature 2021, 590 (7844), 85-88. DOI: 10.1038/s41586-020-03179-3. Link
  12. Carter KP, Smith KF, Tratnjek T, Deblonde GJP, Moreau LM, Rees JA, Booth CH, Abergel RJ “Controlling the Reduction of Chelated Uranyl to Stable Tetravalent Uranium Coordination Complexes in Aqueous Solution” Inorg. Chem.2021, 60, 973-981. DOI: 10.1021/acs.inorgchem.0c03088. Link

2020

  1. Bailey, T. A., Mocko, V., Shield, K. M., An, D. D., Akin, A. C., Birnbaum, E. R., Brugh, M., Cooley, J. C., Engle, J. W., Fassbender, M. E., Gauny, S. S., Lakes, A. L., Nortier, F. M., O’Brien, E. M., Thiemann, S. L., White, F. D., Vermeulen, C., Kozimor, S. A., & Abergel, R. J. (2021). Developing the 134Ce and 134La pair as companion positron emission tomography diagnostic isotopes for 225Ac and 227Th radiotherapeutics. Nature Chemistry, 13(3), 284-289. https://doi.org/10.1038/s41557-020-00598-7. Link
  2. Wang, Y., Zhang, Z., & Abergel, R. J. (2021). Hydroxypyridinone-based stabilization of Np(IV) enabling efficient U/Np/Pu separations in the Adapted PUREX process. Separation and Purification Technology, 259, 118178. https://doi.org/10.1016/j.seppur.2020.118178. Link
  3. Agbo, P., Kanady, J. S., & Abergel, R. J. (2020). Infrared photon pair-production in ligand-sensitized lanthanide nanocrystals. Frontiers in Chemistry, 8. https://doi.org/10.3389/fchem.2020.579942. Link
  4. Lakes, A. L., An, D. D., Gauny, S. S., Ansoborlo, C., Liang, B. H., Rees, J. A., McKnight, K. D., Karsunky, H., & Abergel, R. J. (2020). Evaluating 225Ac and 177Lu radioimmunoconjugates against antibody–drug conjugates for small-cell lung cancer. Molecular Pharmaceutics, 17(11), 4270–4279. https://doi.org/10.1021/acs.molpharmaceut.0c00703. Link
  5. Pallares, R. M., Panyala, N. R., Sturzbecher-Hoehne, M., Illy, M.-C., & Abergel, R. J. (2020). Characterizing the general chelating affinity of serum protein fetuin for lanthanides. Journal of Biological Inorganic Chemistry, 25(7), 941–948. https://doi.org/10.1007/s00775-020-01815-x. Link
  6. Pallares, R. M., Agbo, P., Liu, X., An, D. D., Gauny, S. S., Zeltmann, S. E., Minor, A. M., & Abergel, R. J. (2020). Engineering mesoporous silica nanoparticles for targeted alpha therapy against breast cancer. ACS Applied Materials & Interfaces, 12(36), 40078–40084. https://doi.org/10.1021/acsami.0c11051. Link
  7. Carter, K. P., Pallares, R. M., & Abergel, R. J. (2020). Open questions in transplutonium coordination chemistry. Communications Chemistry, 3(1), 1–4. https://doi.org/10.1038/s42004-020-00338-5. Link
  8. Surbella, R. G., Carter, K. P., Lohrey, T. D., Reilly, D., Kalaj, M., McNamara, B. K., Schwantes, J., & Abergel, R. J. (2020). Rational design of a uranyl metal–organic framework for the capture and colorimetric detection of organic dyes. Chemistry – A European Journal, 26(61), 13819–13825. https://doi.org/https://doi.org/10.1002/chem.201905766. Link
  9. Pallares, R. M., & Abergel, R. J. (2020). Nanoparticles for targeted cancer radiotherapy. Nano Research, 13(11), 2887–2897. https://doi.org/10.1007/s12274-020-2957-8. Link
  10. Pallares, R. M., Sturzbecher-Hoehne, M., Shivaram, N. H., Cryan, J. P., D’Aléo, A., & Abergel, R. J. (2020). Two-photon antenna sensitization of curium: Evidencing metal-driven effects on absorption cross section in f-element complexes. The Journal of Physical Chemistry Letters, 11(15), 6063–6067. https://doi.org/10.1021/acs.jpclett.0c01888. Link
  11. Wang, Y., Deblonde, G. J.-P., & Abergel, R. J. (2020). Hydroxypyridinone derivatives: A low-ph alternative to polyaminocarboxylates for talspeak-like separation of trivalent actinides from lanthanides. ACS Omega, 5(22), 12996–13005. https://doi.org/10.1021/acsomega.0c00873. Link
  12. Carter, K. P., Deblonde, G. J.-P., Lohrey, T. D., Bailey, T. A., An, D. D., Shield, K. M., Lukens, W. W., & Abergel, R. J. (2020). Developing scandium and yttrium coordination chemistry to advance theranostic radiopharmaceuticals. Communications Chemistry, 3(1), 1–7. https://doi.org/10.1038/s42004-020-0307-0. Link
  13. Pallares, R. M., An, D. D., Tewari, P., Wang, E. T., & Abergel, R. J. (2020). Rapid detection of gadolinium-based contrast agents in urine with a chelated europium luminescent probe. ACS Sensors, 5(5), 1281–1286. https://doi.org/10.1021/acssensors.0c00615. Link
  14. Moreau, L. M., Herve, A., Straub, M. D., Russo, D. R., Abergel, R. J., Alayoglu, S., Arnold, J., Braun, A., Deblonde, G. J. P., Liu, Y., Lohrey, T. D., Olive, D. T., Qiao, Y., Rees, J. A., Shuh, D. K., Teat, S. J., Booth, C. H., & Minasian, S. G. (2020). Structural properties of ultra-small thorium and uranium dioxide nanoparticles embedded in a covalent organic framework. Chemical Science, 11(18), 4648–4668. https://doi.org/10.1039/C9SC06117G. Link
  15. Pallares, R. M., Carter, K. P., Zeltmann, S. E., Tratnjek, T., Minor, A. M., & Abergel, R. J. (2020). Selective lanthanide sensing with gold nanoparticles and hydroxypyridinone chelators. Inorganic Chemistry, 59(3), 2030–2036. https://doi.org/10.1021/acs.inorgchem.9b03393. Link
  16. Carter, K. P., Smith, K. F., Tratnjek, T., Shield, K. M., Moreau, L. M., Rees, J. A., Booth, C. H., & Abergel, R. J. (2020). Spontaneous chelation-driven reduction of the neptunyl cation in aqueous solution. Chemistry – A European Journal, 26(11), 2354–2359. https://doi.org/https://doi.org/10.1002/chem.201905695. Link
  17. Abergel, R. J., & Kozimor, S. A. (2020). Innovative f-element chelating strategies. Inorganic Chemistry, 59(1), 4–7. https://doi.org/10.1021/acs.inorgchem.9b03583 Link

2019

  1. Pallares, R. M., & Abergel, R. J. (2020). Transforming lanthanide and actinide chemistry with nanoparticles. Nanoscale, 12(3), 1339–1348. https://doi.org/10.1039/C9NR09175K. Link
  2. Abergel, R. J. (2019). How heavy will we get? Nature Chemistry, 11(12), 1075–1075. https://doi.org/10.1038/s41557-019-0373-z. Link
  3. Lakes, A. L., Rees, J. A., & Abergel, R. J. (2019). Ironed out: A bacterial siderophore primer. In Encyclopedia of Inorganic and Bioinorganic Chemistry (pp. 1–31). American Cancer Society. https://doi.org/10.1002/9781119951438.eibc2627. Link
  4. Ricano, A., Captain, I., Carter, K. P., Nell, B. P., Deblonde, G. J.-P., & Abergel, R. J. (2019). Combinatorial design of multimeric chelating peptoids for selective metal coordination. Chemical Science, 10(28), 6834–6843. https://doi.org/10.1039/C9SC01068H. Link
  5. Deblonde, G. J.-P., Ricano, A., & Abergel, R. J. (2019). Ultra-selective ligand-driven separation of strategic actinides. Nature Communications, 10(1), 1–9. https://doi.org/10.1038/s41467-019-10240-x. Link
  6. Clifton, M. C., Rupert, P. B., Hoette, T. M., Raymond, K. N., Abergel, R. J., & Strong, R. K. (2019). Parsing the functional specificity of Siderocalin/Lipocalin 2/NGAL for siderophores and related small-molecule ligands. Journal of Structural Biology: X, 2, 100008. https://doi.org/10.1016/j.yjsbx.2019.100008. Link
  7. Deblonde, G. J.-P., Lohrey, T. D., & Abergel, R. J. (2019). Inducing selectivity and chirality in group IV metal coordination with high-denticity hydroxypyridinones. Dalton Transactions, 48(23), 8238–8247. https://doi.org/10.1039/C9DT01031A. Link
  8. Agbo, P., Müller, A., Arnedo-Sanchez, L., Ercius, P., M. Minor, A., & J. Abergel, R. (2019). Amplified luminescence in organo-curium nanocrystal hybrids. Nanoscale, 11(16), 7609–7612. https://doi.org/10.1039/C9NR01360A. Link

2018

  1. Deblonde, G. J.-P., Lohrey, T. D., Booth, C. H., Carter, K. P., Parker, B. F., Larsen, Å., Smeets, R., Ryan, O. B., Cuthbertson, A. S., & Abergel, R. J. (2018). Solution thermodynamics and kinetics of metal complexation with a hydroxypyridinone chelator designed for thorium-227 targeted alpha therapy. Inorganic Chemistry, 57(22), 14337–14346. https://doi.org/10.1021/acs.inorgchem.8b02430. Link
  2. Carter, K. P., Jian, J., Pyrch, M. M., Forbes, T. Z., Eaton, T. M., Abergel, R. J., Jong, W. A. de, & Gibson, J. K. (2018). Reductive activation of neptunyl and plutonyl oxo species with a hydroxypyridinone chelating ligand. Chemical Communications, 54(76), 10698–10701. https://doi.org/10.1039/C8CC05626A. Link
  3. Chen, S., Ko, R., Lai, E. P. C., Wyatt, H., Abergel, R. J., & Li, C. (2018). Encapsulated 3,4,3-li(1,2-HOPO) in chitosan nanoparticles for decorporation via inhalation. Radiation Protection Dosimetry, 182(1), 107–111. https://doi.org/10.1093/rpd/ncy139. Link
  4. Muller, A., Deblonde, G. J.-P., Ercius, P., Abergel, R. J., & Minor, A. M. (2018). Electron energy loss spectroscopy of actinides at the nanogram scale. Microscopy and Microanalysis, 24(S1), 444–445. https://doi.org/10.1017/S1431927618002714. Link
  5. Junker, A. K. R., Deblonde, G. J.-P., Abergel, R. J., & Sørensen, T. J. (2018). Investigating subtle 4f vs. 5f coordination differences using kinetically inert Eu(III), Tb(III), and Cm(III) complexes of a coumarin-appended 1,4,7,10-tetraazacyclododecane-1,4,7-triacetate (DO3A) ligand. Dalton Transactions, 47(21), 7362–7369. https://doi.org/10.1039/C8DT01547C. Link
  6. Kelley, M. P., Deblonde, G. J.-P., Su, J., Booth, C. H., Abergel, R. J., Batista, E. R., & Yang, P. (2018). Bond covalency and oxidation state of actinide ions complexed with therapeutic chelating agent 3,4,3-LI(1,2-HOPO). Inorganic Chemistry, 57(9), 5352–5363. https://doi.org/10.1021/acs.inorgchem.8b00345. Link
  7. Rees, J. A.*, Deblonde, G. J.-P.*, An, D. D.*, Ansoborlo, C., Gauny, S. S., & Abergel, R. J. (2018). Evaluating the potential of chelation therapy to prevent and treat gadolinium deposition from MRI contrast agents. Scientific Reports, 8(1), 1–9. https://doi.org/10.1038/s41598-018-22511-6. Link
  8. Deblonde, G. J.-P., Kelley, M. P., Su, J., Batista, E. R., Yang, P., Booth, C. H., & Abergel, R. J. (2018). Spectroscopic and computational characterization of diethylenetriaminepentaacetic acid/transplutonium chelates: Evidencing heterogeneity in the heavy actinide(III) series. Angewandte Chemie International Edition, 57(17), 4521–4526. https://doi.org/10.1002/anie.201709183. Link
  9. Deblonde, G. J.-P., Lohrey, T. D., An, D. D., & Abergel, R. J. (2018). Toxic heavy metal – Pb, Cd, Sn – complexation by the octadentate hydroxypyridinonate ligand archetype 3,4,3-LI(1,2-HOPO). New Journal of Chemistry, 42(10), 7649–7658. https://doi.org/10.1039/C7NJ04559J. Link
  10. Agbo, P., Rees, J. A., & Abergel, R. J. (2018). Actinide biological inorganic chemistry. In Experimental and Theoretical Approaches to Actinide Chemistry (pp. 445–489). John Wiley & Sons, Ltd. https://doi.org/10.1002/9781119115557.ch9. Link

2017

  1. Abergel, R. J., de Jong, W. A., Deblonde, G. J.-P., Dau, P. D., Captain, I., Eaton, T. M., Jian, J., van Stipdonk, M. J., Martens, J., Berden, G., Oomens, J., & Gibson, J. K. (2017). Cleaving off uranyl oxygens through chelation: A mechanistic study in the gas phase. Inorganic Chemistry, 56(21), 12930–12937. https://doi.org/10.1021/acs.inorgchem.7b01720. Link
  2. Deblonde, G. J.-P., Sturzbecher-Hoehne, M., Rupert, P. B., An, D. D., Illy, M.-C., Ralston, C. Y., Brabec, J., de Jong, W. A., Strong, R. K., & Abergel, R. J. (2017). Chelation and stabilization of berkelium in oxidation state + IV. Nature Chemistry, 9(9), 843–849. https://doi.org/10.1038/nchem.2759. Link
  3. An, D. D., Kullgren, B., Jarvis, E. E., & Abergel, R. J. (2017). From early prophylaxis to delayed treatment: Establishing the plutonium decorporation activity window of hydroxypyridinonate chelating agents. Chemico-Biological Interactions, 267, 80–88. https://doi.org/10.1016/j.cbi.2016.03.034. Link

2016

  1. Captain, I., Deblonde, G. J.-P., Rupert, P. B., An, D. D., Illy, M.-C., Rostan, E., Ralston, C. Y., Strong, R. K., & Abergel, R. J. (2016). Engineered recognition of tetravalent zirconium and thorium by chelator–protein systems: Toward flexible radiotherapy and imaging platforms. Inorganic Chemistry, 55(22), 11930–11936. https://doi.org/10.1021/acs.inorgchem.6b02041. Link
  2. Barasch, J., Hollmen, M., Deng, R., Hod, E. A., Rupert, P. B., Abergel, R. J., Allred, B. E., Xu, K., Darrah, S. F., Tekabe, Y., Perlstein, A., Wax, R., Bruck, E., Stauber, J., Corbin, K. A., Buchen, C., Slavkovich, V., Graziano, J., Spitalnik, S. L., … Qiu, A. (2016). Disposal of iron by a mutant form of lipocalin 2. Nature Communications, 7(1), 1–12. https://doi.org/10.1038/ncomms12973. Link
  3. Abergel, R. J. (2016). Chapter 6: Chelation of actinides. In Metal Chelation in Medicine (pp. 183–212). https://doi.org/10.1039/9781782623892-00183. Link
  4. Deblonde, G. J.-P., & Abergel, R. J. (2016). Active actinium. Nature Chemistry, 8(11), 1084–1084. https://doi.org/10.1038/nchem.2653. Link
  5. Dau, P. D., Shuh, D. K., Sturzbecher-Hoehne, M., Abergel, R. J., & Gibson, J. K. (2016). Divalent and trivalent gas-phase coordination complexes of californium: Evaluating the stability of Cf(II). Dalton Transactions, 45(31), 12338–12345. https://doi.org/10.1039/C6DT02414A. Link
  6. Agbo, P., & Abergel, R. J. (2016). Ligand-sensitized lanthanide nanocrystals: Merging solid-state photophysics and molecular solution chemistry. Inorganic Chemistry, 55(20), 9973–9980. https://doi.org/10.1021/acs.inorgchem.6b00879. Link
  7. Abergel, R. J., & Ansoborlo, E. (2016). Curious curium. Nature Chemistry, 8(5), 516–516. https://doi.org/10.1038/nchem.2512. Link
  8. Agbo, P., Xu, T., Sturzbecher-Hoehne, M., & Abergel, R. J. (2016). Enhanced ultraviolet photon capture in ligand-sensitized nanocrystals. ACS Photonics, 3(4), 547–552. https://doi.org/10.1021/acsphotonics.6b00118. Link
  9. Sturzbecher-Hoehne, M., Yang, P., D’Aléo, A., & Abergel, R. J. (2016). Intramolecular sensitization of americium luminescence in solution: Shining light on short-lived forbidden 5f transitions. Dalton Transactions, 45(24), 9912–9919. https://doi.org/10.1039/C6DT00328A. Link
  10. Kamada, K., Namikawa, T., Senatore, S., Matthews, C., Lenne, P.-F., Maury, O., Andraud, C., Ponce-Vargas, M., Le Guennic, B., Jacquemin, D., Agbo, P., An, D. D., Gauny, S. S., Liu, X., Abergel, R. J., Fages, F., & D’Aléo, A. (2016). Boron difluoride curcuminoid fluorophores with enhanced two-photon excited fluorescence emission and versatile living-cell imaging properties. Chemistry – A European Journal, 22(15), 5219–5232. https://doi.org/10.1002/chem.201504903. Link

2015

  1. Allred, B. E., Rupert, P. B., Gauny, S. S., An, D. D., Ralston, C. Y., Sturzbecher-Hoehne, M., Strong, R. K., & Abergel, R. J. (2015). Siderocalin-mediated recognition, sensitization, and cellular uptake of actinides. Proceedings of the National Academy of Sciences, 112(33), 10342–10347. https://doi.org/10.1073/pnas.1508902112. Link
  2. Choi, T. A., Endsley, A. N., Bunin, D. I., Colas, C., An, D. D., Morales‐Rivera, J. A., Villalobos, J. A., Shinn, W. M., Dabbs, J. E., Chang, P. Y., & Abergel, R. J. (2015). Biodistribution of the multidentate hydroxypyridinonate ligand [14C]-3,4,3-LI(1,2-HOPO), a potent actinide decorporation agent. Drug Development Research, 76(3), 107–122. https://doi.org/10.1002/ddr.21246. Link
  3. Sturzbecher-Hoehne, M., Choi, T. A., & Abergel, R. J. (2015). Hydroxypyridinonate complex stability of group (IV) metals and tetravalent f-block elements: The key to the next generation of chelating agents for radiopharmaceuticals. Inorganic Chemistry, 54(7), 3462–3468. https://doi.org/10.1021/acs.inorgchem.5b00033. Link
  4. Choi, T. A., Furimsky, A. M., Swezey, R., Bunin, D. I., Byrge, P., Iyer, L. V., Chang, P. Y., & Abergel, R. J. (2015). In vitro metabolism and stability of the actinide chelating agent 3,4,3-LI(1,2-HOPO). Journal of Pharmaceutical Sciences, 104(5), 1832–1838. https://doi.org/10.1002/jps.24394. Link
  5. Choi, T. A., Costes, S. V., & Abergel, R. J. (2015). Understanding the health impacts and risks of exposure to radiation. In J. Ahn, C. Carson, M. Jensen, K. Juraku, S. Nagasaki, & S. Tanaka (Eds.), Reflections on the Fukushima Daiichi Nuclear Accident: Toward Social-Scientific Literacy and Engineering Resilience (pp. 259–281). Springer International Publishing. https://doi.org/10.1007/978-3-319-12090-4_13. Link
  6. Liu, M., Wang, J., Wu, X., Wang, E., Abergel, R. J., Shuh, D. K., Raymond, K. N., & Liu, P. (2015). Characterization, HPLC method development and impurity identification for 3,4,3-LI(1,2-HOPO), a potent actinide chelator for radionuclide decorporation. Journal of Pharmaceutical and Biomedical Analysis, 102, 443–449. https://doi.org/10.1016/j.jpba.2014.10.015. Link

2014

  1. Abergel RJ. Les futurs agents chélatants sont déjà là. Biofutur. 2014, 353, 47-51. Link
  2. Panyala, N. R., Sturzbecher-Hoehne, M., & Abergel, R. J. (2014). Identification of process related trace level impurities in the actinide decorporation agent 3,4,3-LI(1,2-HOPO): Nozzle–skimmer fragmentation via ESI LC–QTOFMS. Journal of Pharmaceutical and Biomedical Analysis, 100, 157–166. https://doi.org/10.1016/j.jpba.2014.08.004. Link
  3. An, D. D., Villalobos, J. A., Morales-Rivera, J. A., Rosen, C. J., Bjornstad, K. A., Gauny, S. S., Choi, T. A., Sturzbecher-Hoehne, M., & Abergel, R. J. (2014). 238Pu elimination profiles after delayed treatment with 3,4,3LI(1,2HOPO) in female and male Swiss-Webster mice. International Journal of Radiation Biology, 90(11), 1055–1061. https://doi.org/10.3109/09553002.2014.925150. Link
  4. Sturzbecher-Hoehne, M., Kullgren, B., Jarvis, E. E., An, D. D., & Abergel, R. J. (2014). Highly luminescent and stable hydroxypyridinonate complexes: A step towards new curium decontamination strategies. Chemistry – A European Journal, 20(32), 9962–9968. https://doi.org/10.1002/chem.201402103 . Link

2013

  1. Deblonde, G. J.-P., Sturzbecher-Hoehne, M., & Abergel, R. J. (2013). Solution thermodynamic stability of complexes formed with the octadentate hydroxypyridinonate ligand 3,4,3-LI(1,2-HOPO): A critical feature for efficient chelation of lanthanide(IV) and actinide(IV) ions. Inorganic Chemistry, 52(15), 8805–8811. https://doi.org/10.1021/ic4010246. Link
  2. Sturzbecher-Hoehne, M., Deblonde, G. J.-P., & Abergel, R. J. (2013). Solution thermodynamic evaluation of hydroxypyridinonate chelators 3,4,3-LI(1,2-HOPO) and 5-LIO(Me-3,2-HOPO) for UO2(VI) and Th(IV) decorporation. Radiochimica Acta, 101(6), 359–366. https://doi.org/10.1524/ract.2013.2047. Link
  3. Deblonde, G. J.-P., Sturzbecher-Hoehne, M., Mason, A. B., & Abergel, R. J. (2013). Receptor recognition of transferrin bound to lanthanides and actinides: A discriminating step in cellular acquisition of f-block metals. Metallomics, 5(6), 619–626. https://doi.org/10.1039/C3MT20237B. Link
  4. Bunin, D. I., Chang, P. Y., Doppalapudi, R. S., Riccio, E. S., An, D., Jarvis, E. E., Kullgren, B., & Abergel, R. J. (2013). Dose-dependent efficacy and safety toxicology of hydroxypyridinonate actinide decorporation agents in rodents: Towards a safe and effective human dosing regimen. Radiation Research, 179(2), 171–182. https://doi.org/10.1667/RR3115.1. Link
  5. Sturzbecher-Hoehne, M., Goujon, C., Deblonde, G. J.-P., Mason, A. B., & Abergel, R. J. (2013). Sensitizing curium luminescence through an antenna protein to investigate biological actinide transport mechanisms. Journal of the American Chemical Society, 135(7), 2676–2683. https://doi.org/10.1021/ja310957f. Link

2012

  1. Kullgren, B., Jarvis, E. E., An, D. D., & Abergel, R. J. (2012). Actinide chelation: Biodistribution and in vivo complex stability of the targeted metal ions. Toxicology Mechanisms and Methods, 23(1), 18–26. https://doi.org/10.3109/15376516.2012.728641. Link
  2. Jarvis, E. E., An, D. D., Kullgren, B., & Abergel, R. J. (2012). Significance of single variables in defining adequate animal models to assess the efficacy of new radionuclide decorporation agents: Using the contamination dose as an example. Drug Development Research, 73(5), 281–289. https://doi.org/10.1002/ddr.21020. Link

2011

  1. Correnti, C., Clifton, M. C., Abergel, R. J., Allred, B., Hoette, T. M., Ruiz, M., Cancedda, R., Raymond, K. N., Descalzi, F., & Strong, R. K. (2011). Galline ex-fabp is an antibacterial siderocalin and a lysophosphatidic acid sensor functioning through dual ligand specificities. Structure, 19(12), 1796–1806. https://doi.org/10.1016/j.str.2011.09.019. Link
  2. Abergel, R. J., & Raymond, K. N. (2011). Multidentate terephthalamidate and hydroxypyridonate ligands: Towards new orally active chelators. Hemoglobin, 35(3), 276–290. https://doi.org/10.3109/03630269.2011.560771. Link
  3. Chang, P. Y., Bunin, D. I., Gow, J., Swezey, R., Shinn, W., Shuh, D. K., & Abergel, R. J. (2011). Analytical methods for the bioavailability evaluation of hydroxypyridinonate actinide decorporation agents in pre-clinical pharmacokinetic studies. Journal of Chromatography & Separation Techniques, 4(7), 1–6. https://doi.org/10.4172/2157-7064.1000196. Link
  4. Sturzbecher-Hoehne, M., Leung, C. N. P., D’Aléo, A., Kullgren, B., Prigent, A.-L., Shuh, D. K., Raymond, K. N., & Abergel, R. J. (2011). 3,4,3-LI(1,2-HOPO): In vitro formation of highly stable lanthanide complexes translates into efficacious in vivo europium decorporation. Dalton Transactions, 40(33), 8340–8346. https://doi.org/10.1039/C1DT10840A. Link

2010

  1. Abergel, R. J., Durbin, P. W., Kullgren, B., Ebbe, S. N., Xu, J., Chang, P. Y., Bunin, D. I., Blakely, E. A., Bjornstad, K. A., Rosen, C. J., Shuh, D. K., & Raymond, K. N. (2010). Biomimetic actinide chelators: An update on the preclinical development of the orally active hydroxypyridonate decorporation agents 3,4,3-LI(1,2-HOPO) and 5-LIO(Me-3,2-HOPO). Health Physics, 99(3), 401–407. https://doi.org/10.1097/HP.0b013e3181c21273. Link

Past

  1. Abergel, R. J., D’Aléo, A., Ng Pak Leung, C., Shuh, D. K., & Raymond, K. N. (2009). Using the antenna effect as a spectroscopic tool: Photophysics and solution thermodynamics of the model luminescent hydroxypyridonate complex [EuIII(3,4,3-LI(1,2-HOPO))]−. Inorganic Chemistry, 48(23), 10868–10870. https://doi.org/10.1021/ic9013703. Link
  2. Wilson, M. K., Abergel, R. J., Arceneaux, J. E. L., Raymond, K. N., & Byers, B. R. (2009). Temporal production of the two Bacillus anthracis siderophores, petrobactin and bacillibactin. BioMetals, 23(1), 129. https://doi.org/10.1007/s10534-009-9272-x. Link
  3. Abergel, R. J., Zawadzka, A. M., Hoette, T. M., & Raymond, K. N. (2009). Enzymatic hydrolysis of trilactone siderophores: Where chiral recognition occurs in enterobactin and bacillibactin iron transport. Journal of the American Chemical Society, 131(35), 12682–12692. https://doi.org/10.1021/ja903051q. Link
  4. Zawadzka, A. M., Abergel, R. J., Nichiporuk, R., Andersen, U. N., & Raymond, K. N. (2009). Siderophore-mediated iron acquisition systems in bacillus cereus: Identification of receptors for anthrax virulence-associated petrobactin,. Biochemistry, 48(16), 3645–3657. https://doi.org/10.1021/bi8018674 . Link
  5. Hoette, T. M., Abergel, R. J., Xu, J., Strong, R. K., & Raymond, K. N. (2008). The role of electrostatics in siderophore recognition by the immunoprotein siderocalin. Journal of the American Chemical Society, 130(51), 17584–17592. https://doi.org/10.1021/ja8074665. Link
  6. Abergel, R. J., Clifton, M. C., Pizarro, J. C., Warner, J. A., Shuh, D. K., Strong, R. K., & Raymond, K. N. (2008). The siderocalin/enterobactin interaction: A link between mammalian immunity and bacterial iron transport. Journal of the American Chemical Society, 130(34), 11524–11534. https://doi.org/10.1021/ja803524w. Link
  7. Abergel, R. J., Zawadzka, A. M., & Raymond, K. N. (2008). Petrobactin-mediated iron transport in pathogenic bacteria: Coordination chemistry of an unusual 3,4-catecholate/citrate siderophore. Journal of the American Chemical Society, 130(7), 2124–2125. https://doi.org/10.1021/ja077202g. Link
  8. Abergel, R. J., & Raymond, K. N. (2008). Terephthalamide-containing ligands: Fast removal of iron from transferrin. Journal of Biological Inorganic Chemistry, 13(2), 229–240. https://doi.org/10.1007/s00775-007-0314-y. Link
  9. Abergel, R. J., Wilson, M. K., Arceneaux, J. E. L., Hoette, T. M., Strong, R. K., Byers, B. R., & Raymond, K. N. (2006). Anthrax pathogen evades the mammalian immune system through stealth siderophore production. Proceedings of the National Academy of Sciences, 103(49), 18499–18503. https://doi.org/10.1073/pnas.0607055103. Link
  10. Fischbach, M. A., Lin, H., Zhou, L., Yu, Y., Abergel, R. J., Liu, D. R., Raymond, K. N., Wanner, B. L., Strong, R. K., Walsh, C. T., Aderem, A., & Smith, K. D. (2006). The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2. Proceedings of the National Academy of Sciences, 103(44), 16502–16507. https://doi.org/10.1073/pnas.0604636103. Link
  11. Abergel, R. J., Moore, E. G., Strong, R. K., & Raymond, K. N. (2006). Microbial evasion of the immune system: Structural modifications of enterobactin impair siderocalin recognition. Journal of the American Chemical Society, 128(34), 10998–10999. https://doi.org/10.1021/ja062476+. Link
  12. Wilson, M. K., Abergel, R. J., Raymond, K. N., Arceneaux, J. E. L., & Byers, B. R. (2006). Siderophores of Bacillus anthracis, Bacillus cereus, and Bacillus thuringiensis. Biochemical and Biophysical Research Communications, 348(1), 320–325. https://doi.org/10.1016/j.bbrc.2006.07.055. Link
  13. Abergel, R. J., Warner, J. A., Shuh, D. K., & Raymond, K. N. (2006). Enterobactin protonation and iron release: Structural characterization of the salicylate coordination shift in ferric enterobactin. Journal of the American Chemical Society, 128(27), 8920–8931. https://doi.org/10.1021/ja062046j. Link
  14. Abergel, R. J., & Raymond, K. N. (2006). Synthesis and thermodynamic evaluation of mixed hexadentate linear iron chelators containing hydroxypyridinone and terephthalamide units. Inorganic Chemistry, 45(9), 3622–3631. https://doi.org/10.1021/ic052111a. Link
  15. Abergel, R. J., & Dinca, M. (2004). 9,10-Di­bromo­triptycene. Acta Crystallographica Section E, 60(7), o1248–o1249. https://doi.org/10.1107/S1600536804013753. Link