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BioActinide Chemistry Group @ Berkeley

Publications & Patents

We publish our research in peer-reviewed journals and patent our discoveries at Berkeley Lab and UC Berkeley.

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Google Patents

2023

  1. Pallares, R. M., Li, Y., Abergel, R. J., Understanding the biological behavior of lanthanides and actinides through omics approaches. TrAC. 2023, 167, 117251. DOI: 10.1016/j.trac.2023.117251. Link
  2. Woods, J. J., Cosby, A. G., Wacker, J. N., Aguirre Quintana, L. M., Peterson, A., Minasian, S. G., Abergel, R. J., Macrocyclic 1,2-Hydroxypyridinone-Based Chelators as Potential Ligands for Thorium-227 and Zirconium-89 Radiopharmaceuticals. Inorg. Chem. 2023, Advance Article. DOI: 10.1021/acs.inorgchem.3c02164. Link
  1. Cosby, A. G., Arino, T., Bailey, T. A., Buerger, M., Woods, J. J., Aguirre Quintana, L. M., Alvarenga Vasquez, J. V., Wacker, J. N., Gaiser, A. N., Strong, R. K., Abergel, R. J. Siderocalin fusion proteins enable a new 86Y/90Y theranostic approach. RSC Chem. Bio. 2023, 4, 587-591. DOI: 10.1039/D3CB00050H. Link
  1. Emerzian, S. R., Wu, T., Vaidya, R., Tang, S. Y., Abergel, R. J., Keaveny, T. M. Relative Effects of Radiation-Induced Changes in Bone Mass, Structure, and Tissue Material on Vertebral Strength in a Rat Model. J. Bone Min. Res. 2023. 38, 1032-1042. DOI: 10.1002/jbmr.4828. Link
  2. Pallares, R. M., Karstens, S., Arino, T., Minor, A. M., Abergel, R. J. Engineering the Interface of Ceria and Silver Janus Nanoparticles for Enhanced Catalytic Performance in 4-Nitrophenol Conversion. ACS Appl. Nano Mater. 2023, 6, 8141-8145. DOI: 10.1021/acsanm.3c01394. Link
  3. Wang, Y., Mezyk, S., McLachlan, J., Grimes, T., Zalupski, P., O’Bryan, H., Cook, A., Abergel, R. J., Horne, G. Radiolytic Evaluation of 3,4,3-LI(1,2-HOPO) in Aqueous Solutions J. Phys. Chem. 2023. 127, 3931-3938. DOI: 10.1021/acs.jpcb.3c01469. Link
  4. Wang, Y., Shield, K. M., Abergel, R. J. Hydrophilic Chelators for Aqueous Reprocessing of Spent Nuclear Fuel. Sep. Purif. Rev. 2023. DOI: 10.1080/15422119.2023.2182220. Link
  5. Wang, Y., Abergel, R. J. Radiochemical Separation Techniques in Classroom Settings. J. Chem. Ed. 2023. 100, 1603-1612. DOI: 10.1021/acs.jchemed.2c01193. Link

2022

  1. Pallares, R. M., Abergel, R. J. Development of radiopharmaceuticals for targeted alpha therapy: Where do we stand? Front. Med. 2022, 9, 1020188. DOI: 110.3389/fmed.2022.1020188. Link
  2. Pallares, R. M., An, D. D., Hebert, S., Loguinov, A., Proctor, M., Villalobos, J. A., Bjornstad, K. A., Rosen, C. J., Vulpe, C., Abergel, R. J. Identifying Toxicity Mechanisms Associated with Early Lanthanide Exposure through Multidimensional Genome-Wide Screening. ACS Omega 2022, 7, 34412-34419. DOI: 10.1021/acsomega.2c04045. Link
  3. Pallares, R. M., Flick, M., Shield, K. M., Bailey, T. A., Velappan, N., Lillo, A. M., Abergel, R. J. Development of an Actinium-225 Radioimmunoconjugate for Targeted Alpha Therapy against SARS-CoV-2. New J. Chem. 2022, 46, 15795-15798. DOI: 10.1039/D2NJ02617A. Link
  4. Bailey, T. A., Wacker, J. N., An, D. D., Carter, K. P., Davis, R. C., Mocko, V., Larrabee, J., Shield, K. M., Lam, M. N., Booth, C. H., Abergel, R. J. Evaluation of 134Ce as a PET imaging surrogate for antibody drug conjugates incorporating 225Ac. Nucl. Med. Biol. 2022, 110 28-36. DOI: 10.1016/j.nucmedbio.2022.04.007. Link
  5. Pallares, R. M., Jarvis, E., An, D. D., Wu, C. H., Chang, P. Y., Abergel, R. J. Toxicogenomic assessment of organ-specific responses following plutonium internal contamination. Environ. Adv. 2022, 8, 100245. DOI: 10.1016/j.envadv.2022.100245. Link
  6. Carter, K. P., Wacker, J. N., Smith, K. F., Deblonde. G. J. P., Moreau, L. M., Rees, J. A., Booth, C. H., Abergel, R. J. In Situ Beam Reduction of PuIV and BkIV as a Route to Trivalent Transuranic Coordination Complexes with Hydroxypyridinone Chelators. J. Synchrotron Radiat. 2022, 29, 315-322. DOI: 10.1107/S1600577522000200. Link
  7. Abergel, R. J., Aris, J., Bolch, W. E., Dewji, S. A., Golden, A., Hooper, D. A., Margot, D. D., Menker, C. G., Paunesku, T., Schaue, D., Woloschak, G. E. The Enduring Legacy of Marie Curie: Impacts of Radium in 21st Century Radiological and Medical Sciences. Int. J. Radiat. Biol. 2022, 98, 267-275. DOI: 10.1080/09553002.2022.2027542. Link
  8. Pallares, R. M., An, D. D., Hebert, S., Faulkner, D., Loguinov, A., Proctor, M., Villalobos, J. A., Bjornstad, K. A., Rosen, C. J., Vulpe, C., Abergel, R. J. Delineating Toxicity Mechanisms Associated with MRI Contrast Enhancement through a Multidimensional Toxicogenomic Profiling of Gadolinium. Mol. Omics. 2022, 18, 237-248. DOI: 10.1039/D1MO00267H. Link
  9. Pallares, R. M., Charrier, M., Tejedor-Sanz, S., Li, D., Ashby, P. D., Ajo-Franklin, C. M., Ralston, C. Y., Abergel, R. J. Precision Engineering of 2D Protein Layers as Chelating Biogenic Scaffolds for Selective Recovery of Rare-Earth Elements. J. Am. Chem. Soc. 2022, 144, 854-861. DOI: 10.1021/jacs.1c10802. Link

2021

  1. Pallares, R. M., An, D. D., Hebert, S., Faulkner, D., Loguinov, A., Proctor, M., Villalobos, J. A., Bjornstad, K. A., Rosen, C. J., Vulpe, C., Abergel, R. J. Multidimensional genome-wide screening in yeast provides mechanistic insights into europium toxicity. Metallomics 2021, 13. DOI: 10.1093/mtomcs/mfab061. Link
  2. Alrich, K., Livshits, M., Stromberg, L., Janicke, M. T., Lam, M. N., Stein, B. W., Wagner, G., Abergel, R. J., Mukundan, H., Kozimor, S. A., Lilley, L. M. ThIV–Desferrioxamine: Characterization of a Fluorescent Bacterial Probe. Dalton Trans. 2021, 50, 15310-15320. DOI: 10.1039/D1DT02177J. Link
  3. Pallares, R. M., Hebert, S., Sturzbecher-Hoehne, M., Abergel, R. J. Chelator-assisted high performance liquid chromatographic separation of trivalent lanthanides and actinides. New J. Chem. 2021, 45, 14364-14368. DOI: 10.1039/D1NJ01966J. Link
  4. Pallares, R. M., Faulkner, D., An, D. D., Hebert, S., Loguinov, A., Proctor, M., Villalobos, J. A., Bjornstad, K. A., Rosen, C. J., Vulpe, C., Abergel, R. J. Genome-wide toxicogenomic study of the lanthanides sheds light on the selective toxicity mechanisms associated with critical materials. Proc. Natl. Acad. Sci. 2021, 118. DOI: 10.1073/pnas.2025952118. Link
  5. Bessen NP, Popov IA, Heathman CR, Grimes TS, Zalupski PR, Moreau LM, Smith KF, Booth CH, Abergel RJ, Batista ER, Yang P, Shafer JC (2021). Complexation of Lanthanides and Heavy Actinides with Aqueous Sulfur-Donating Ligands. Inorg. Chem. 2021, 60 (9), 6125-6134. DOI: 10.1021/acs.inorgchem.1c00257. Link
  6. Arnedo-Sanchez, L., Smith, K. F., Deblonde, G. J. P., Carter, K. P., Moreau, L. M., Rees, J. A., Tratnjek, T., Booth, C. H., Abergel, R. J. Combining the Best of Two Chelating Titans: A Hydroxypyridinone‐Decorated Macrocyclic Ligand for Efficient and Concomitant Complexation and Sensitized Luminescence of f‐Elements. ChemPlusChem 2021, 86, 483-491. DOI: 10.1002/cplu.202100083. Link
  7. Pallares, R. M., An, D. D., Deblonde, G. J. P., Kullgren, B., Gauny, S. S., Jarvis, E. E., Abergel, R. J. Efficient discrimination of transplutonium actinides by in vivo models. Chem. Sci. 2021, 12, 5295-5301. DOI: 10.1039/D0SC06610A. Link
  8. Pallares, R. M., Carter, K. P., Faulkner, D., Abergel, R. J. Macromolecular crystallography for f-element complex characterization. Meth. Enzymol. 2021, 651, 139-155. DOI: 10.1016/bs.mie.2021.01.014. Link
  9. Mueller, A., Deblonde, G. J. P., Ercius, P., Zeltmann, S. E., Abergel, R. J., Minor, A. M. Probing electronic structure in berkelium and californium via an electron microscopy nanosampling approach Nat. Comm. 2021, 12, 1-6. DOI: 10.1038/s41467-021-21189-1. Link
  10. Pallares, R. M., Abergel, R. J. Diagnostic, Prognostic and Therapeutic Use of Radiopharmaceuticals in the Context of SARS-CoV-2. ACS Pharm. Trans. Sci. 2021, 4, 1-7. DOI: 10.1021/acsptsci.0c00186. Link
  11. Carter K. P., Shield K. M., Smith, K. F., Jones, Z. R., Wacker, J. N., Arnedo-Sanchez, L., Mattox, T. M., Moreau, L. M., Knope, K. E., Kozimor, S. A., Booth, C. H., Abergel, R. J. Structural and Spectroscopic Characterization of an Einsteinium Complex. Nature. 2021, 590, 85-88. DOI: 10.1038/s41586-020-03179-3. Link
  12. Carter, K. P., Smith, K. F., Tratnjek, T., Deblonde, G. J. P., Moreau, L. M. , Rees, J. A., Booth, C. H., Abergel, R. J. Controlling the Reduction of Chelated Uranyl to Stable Tetravalent Uranium Coordination Complexes in Aqueous Solution. Inorg. Chem. 2021, 60, 973-981. DOI: 10.1021/acs.inorgchem.0c03088. Link
  13. Bailey, T. A., Mocko, V., Shield, K. M., An, D. D., Akin, A. C., Birnbaum, E. R., Brugh, M., Cooley, J. C., Engle, J. W., Fassbender, M. E., Gauny, S. S., Lakes, A. L., Nortier, F. M., O’Brien, E. M., Thiemann, S. L., White, F. D., Vermeulen, C., Kozimor, S. A., & Abergel, R. J. Developing the 134Ce and 134La pair as companion positron emission tomography diagnostic isotopes for 225Ac and 227Th radiotherapeutics. Nature Chemistry, 2021, 13, 284-289. DOI: 10.1038/s41557-020-00598-7. Link
  14. Wang, Y., Zhang, Z., & Abergel, R. J. (2021). Hydroxypyridinone-based stabilization of Np(IV) enabling efficient U/Np/Pu separations in the Adapted PUREX process. Separation and Purification Technology, 2021, 259, 118178. DOI: 10.1016/j.seppur.2020.118178. Link

2020

  1. Agbo, P., Kanady, J. S., & Abergel, R. J. Infrared photon pair-production in ligand-sensitized lanthanide nanocrystals. Frontiers in Chemistry, 8. DOI: 10.3389/fchem.2020.579942. Link
  2. Lakes, A. L., An, D. D., Gauny, S. S., Ansoborlo, C., Liang, B. H., Rees, J. A., McKnight, K. D., Karsunky, H., & Abergel, R. J. Evaluating 225Ac and 177Lu radioimmunoconjugates against antibody–drug conjugates for small-cell lung cancer. Mol. Pharm., 2020, 17, 4270–4279. DOI: 10.1021/acs.molpharmaceut.0c00703. Link
  3. Pallares, R. M., Panyala, N. R., Sturzbecher-Hoehne, M., Illy, M.-C., & Abergel, R. J. Characterizing the general chelating affinity of serum protein fetuin for lanthanides. Journal of Biological Inorganic Chemistry, 2020, 25, 941–948. DOI: 10.1007/s00775-020-01815-x. Link
  4. Pallares, R. M., Agbo, P., Liu, X., An, D. D., Gauny, S. S., Zeltmann, S. E., Minor, A. M., & Abergel, R. J. Engineering mesoporous silica nanoparticles for targeted alpha therapy against breast cancer. ACS Applied Materials & Interfaces, 2020, 12, 40078–40084. DOI: 10.1021/acsami.0c11051. Link
  5. Carter, K. P., Pallares, R. M., & Abergel, R. J. Open questions in transplutonium coordination chemistry. Communications Chemistry, 2020, 3, 1–4. DOI: 10.1038/s42004-020-00338-5. Link
  6. Surbella, R. G., Carter, K. P., Lohrey, T. D., Reilly, D., Kalaj, M., McNamara, B. K., Schwantes, J., & Abergel, R. J. Rational design of a uranyl metal–organic framework for the capture and colorimetric detection of organic dyes. Chemistry – Eur. J., 2020, 26, 13819–13825. DOI: 10.1002/chem.201905766. Link
  7. Pallares, R. M., & Abergel, R. J. Nanoparticles for targeted cancer radiotherapy. Nano Research, 2020, 13, 2887–2897. DOI: 10.1007/s12274-020-2957-8. Link
  8. Pallares, R. M., Sturzbecher-Hoehne, M., Shivaram, N. H., Cryan, J. P., D’Aléo, A., & Abergel, R. J. Two-photon antenna sensitization of curium: Evidencing metal-driven effects on absorption cross section in f-element complexes. The Journal of Physical Chemistry Letters, 2020, 11, 6063–6067. DOI: 10.1021/acs.jpclett.0c01888. Link
  9. Wang, Y., Deblonde, G. J.-P., & Abergel, R. J. Hydroxypyridinone derivatives: A low-ph alternative to polyaminocarboxylates for talspeak-like separation of trivalent actinides from lanthanides. ACS Omega, 2020, 5, 12996–13005. DOI: 10.1021/acsomega.0c00873. Link
  10. Carter, K. P., Deblonde, G. J.-P., Lohrey, T. D., Bailey, T. A., An, D. D., Shield, K. M., Lukens, W. W., & Abergel, R. J. Developing scandium and yttrium coordination chemistry to advance theranostic radiopharmaceuticals. Communications Chemistry, 2020, 3, 1–7. DOI: 10.1038/s42004-020-0307-0. Link
  11. Pallares, R. M., An, D. D., Tewari, P., Wang, E. T., & Abergel, R. J. Rapid detection of gadolinium-based contrast agents in urine with a chelated europium luminescent probe. ACS Sensors, 2020, 5, 1281–1286. DOI: 10.1021/acssensors.0c00615. Link
  12. Moreau, L. M., Herve, A., Straub, M. D., Russo, D. R., Abergel, R. J., Alayoglu, S., Arnold, J., Braun, A., Deblonde, G. J. P., Liu, Y., Lohrey, T. D., Olive, D. T., Qiao, Y., Rees, J. A., Shuh, D. K., Teat, S. J., Booth, C. H., & Minasian, S. G. Structural properties of ultra-small thorium and uranium dioxide nanoparticles embedded in a covalent organic framework. Chem. Sci., 2020, 11, 4648–4668. DOI: 10.1039/C9SC06117G. Link
  13. Pallares, R. M., Carter, K. P., Zeltmann, S. E., Tratnjek, T., Minor, A. M., & Abergel, R. J Selective lanthanide sensing with gold nanoparticles and hydroxypyridinone chelators. Inorg. Chem., 2020, 59, 2030–2036. DOI: 10.1021/acs.inorgchem.9b03393. Link
  14. Carter, K. P., Smith, K. F., Tratnjek, T., Shield, K. M., Moreau, L. M., Rees, J. A., Booth, C. H., & Abergel, R. J. Spontaneous chelation-driven reduction of the neptunyl cation in aqueous solution. Chemistry – Eur. J., 2020, 26, 2354–2359. DOI: 10.1002/chem.201905695. Link
  15. Abergel, R. J., & Kozimor, S. A. Innovative f-element chelating strategies. Inorg. Chem., 2020, 59, 4–7. DOI: 10.1021/acs.inorgchem.9b03583 Link

2019

  1. Pallares, R. M., & Abergel, R. J. Transforming lanthanide and actinide chemistry with nanoparticles. Nanoscale, 2019, 12, 1339–1348. DOI: 10.1039/C9NR09175K. Link
  2. Abergel, R. J. How heavy will we get? Nature Chemistry, 2019, 11, 1075–1075. DOI: 10.1038/s41557-019-0373-z. Link
  3. Lakes, A. L., Rees, J. A., & Abergel, R. J. Ironed out: A bacterial siderophore primer. In Encyclopedia of Inorganic and Bioinorganic Chemistry (pp. 1–31). American Cancer Society. DOI: 10.1002/9781119951438.eibc2627. Link
  4. Ricano, A., Captain, I., Carter, K. P., Nell, B. P., Deblonde, G. J.-P., & Abergel, R. J. Combinatorial design of multimeric chelating peptoids for selective metal coordination. Chem. Sci., 2019, 10, 6834–6843. DOI: 10.1039/C9SC01068H. Link
  5. Deblonde, G. J.-P., Ricano, A., & Abergel, R. J. Ultra-selective ligand-driven separation of strategic actinides. Nature Communications, 2019, 10, 1–9. DOI: 10.1038/s41467-019-10240-x. Link
  6. Clifton, M. C., Rupert, P. B., Hoette, T. M., Raymond, K. N., Abergel, R. J., & Strong, R. K. Parsing the functional specificity of Siderocalin/Lipocalin 2/NGAL for siderophores and related small-molecule ligands. Journal of Structural Biology, 2019, 2, 100008. DOI: 10.1016/j.yjsbx.2019.100008. Link
  7. Deblonde, G. J.-P., Lohrey, T. D., & Abergel, R. J. (2019). Inducing selectivity and chirality in group IV metal coordination with high-denticity hydroxypyridinones. Dalton Trans., 2019, 48, 8238–8247. DOI: 10.1039/C9DT01031A. Link
  8. Agbo, P., Müller, A., Arnedo-Sanchez, L., Ercius, P., M. Minor, A., & J. Abergel, R. Amplified luminescence in organo-curium nanocrystal hybrids. Nanoscale, 2019, 11, 7609–7612. DOI: 0.1039/C9NR01360A. Link

2018

  1. Deblonde, G. J.-P., Lohrey, T. D., Booth, C. H., Carter, K. P., Parker, B. F., Larsen, Å., Smeets, R., Ryan, O. B., Cuthbertson, A. S., & Abergel, R. J. Solution thermodynamics and kinetics of metal complexation with a hydroxypyridinone chelator designed for thorium-227 targeted alpha therapy. Inorg. Chem., 2018, 57, 14337–14346. DOI: 10.1021/acs.inorgchem.8b02430. Link
  2. Carter, K. P., Jian, J., Pyrch, M. M., Forbes, T. Z., Eaton, T. M., Abergel, R. J., Jong, W. A. de, & Gibson, J. K. Reductive activation of neptunyl and plutonyl oxo species with a hydroxypyridinone chelating ligand. Chem. Comm., 2018, 54, 10698–10701. DOI: 10.1039/C8CC05626A. Link
  3. Chen, S., Ko, R., Lai, E. P. C., Wyatt, H., Abergel, R. J., & Li, C. Encapsulated 3,4,3-li(1,2-HOPO) in chitosan nanoparticles for decorporation via inhalation. Radiation Protection Dosimetry, 2018, 182, 107–111. DOI: 10.1093/rpd/ncy139. Link
  4. Muller, A., Deblonde, G. J.-P., Ercius, P., Abergel, R. J., & Minor, A. M. Electron energy loss spectroscopy of actinides at the nanogram scale. Microscopy and Microanalysis, 2018, 24, 444–445. DOI: 10.1017/S1431927618002714. Link
  5. Junker, A. K. R., Deblonde, G. J.-P., Abergel, R. J., & Sørensen, T. J. Investigating subtle 4f vs. 5f coordination differences using kinetically inert Eu(III), Tb(III), and Cm(III) complexes of a coumarin-appended 1,4,7,10-tetraazacyclododecane-1,4,7-triacetate (DO3A) ligand. Dalton Trans., 2018, 47, 7362–7369. DOI: 10.1039/C8DT01547C. Link
  6. Kelley, M. P., Deblonde, G. J.-P., Su, J., Booth, C. H., Abergel, R. J., Batista, E. R., & Yang, P. Bond covalency and oxidation state of actinide ions complexed with therapeutic chelating agent 3,4,3-LI(1,2-HOPO). Inorg. Chem., 2018, 57, 5352–5363. DOI: 10.1021/acs.inorgchem.8b00345. Link
  7. Rees, J. A., Deblonde, G. J.-P., An, D. D., Ansoborlo, C., Gauny, S. S., & Abergel, R. J. Evaluating the potential of chelation therapy to prevent and treat gadolinium deposition from MRI contrast agents. Scientific Reports, 2018, 8, 1–9. DOI: 10.1038/s41598-018-22511-6. Link
  8. Deblonde, G. J.-P., Kelley, M. P., Su, J., Batista, E. R., Yang, P., Booth, C. H., & Abergel, R. J. Spectroscopic and computational characterization of diethylenetriaminepentaacetic acid/transplutonium chelates: Evidencing heterogeneity in the heavy actinide(III) series. Angew. Chem. Int. Ed., 2018, 57, 4521–4526. DOI: 10.1002/anie.201709183. Link
  9. Deblonde, G. J.-P., Lohrey, T. D., An, D. D., & Abergel, R. J. Toxic heavy metal – Pb, Cd, Sn – complexation by the octadentate hydroxypyridinonate ligand archetype 3,4,3-LI(1,2-HOPO). New Journal of Chemistry, 2018, 42, 7649–7658.DOI: 10.1039/C7NJ04559J. Link
  10. Agbo, P., Rees, J. A., & Abergel, R. J. Actinide biological inorganic chemistry. In Experimental and Theoretical Approaches to Actinide Chemistry (pp. 445–489). John Wiley & Sons, Ltd. DOI: 10.1002/9781119115557.ch9. Link

2017

  1. Abergel, R. J., de Jong, W. A., Deblonde, G. J.-P., Dau, P. D., Captain, I., Eaton, T. M., Jian, J., van Stipdonk, M. J., Martens, J., Berden, G., Oomens, J., & Gibson, J. K. Cleaving off uranyl oxygens through chelation: A mechanistic study in the gas phase. Inorg. Chem., 2017, 56, 12930–12937. DOI: 10.1021/acs.inorgchem.7b01720. Link
  2. Deblonde, G. J.-P., Sturzbecher-Hoehne, M., Rupert, P. B., An, D. D., Illy, M.-C., Ralston, C. Y., Brabec, J., de Jong, W. A., Strong, R. K., & Abergel, R. J. Chelation and stabilization of berkelium in oxidation state + IV. Nature Chemistry, 2017, 9, 843–849. DOI: 10.1038/nchem.2759. Link
  3. An, D. D., Kullgren, B., Jarvis, E. E., & Abergel, R. J. From early prophylaxis to delayed treatment: Establishing the plutonium decorporation activity window of hydroxypyridinonate chelating agents. Chemico-Biological Interactions, 2017, 267, 80–88. DOI: 10.1016/j.cbi.2016.03.034. Link

2016

  1. Captain, I., Deblonde, G. J.-P., Rupert, P. B., An, D. D., Illy, M.-C., Rostan, E., Ralston, C. Y., Strong, R. K., & Abergel, R. J. Engineered recognition of tetravalent zirconium and thorium by chelator–protein systems: Toward flexible radiotherapy and imaging platforms. Inorg. Chem., 2016, 5, 11930–11936. DOI: 10.1021/acs.inorgchem.6b02041. Link
  2. Barasch, J., Hollmen, M., Deng, R., Hod, E. A., Rupert, P. B., Abergel, R. J., Allred, B. E., Xu, K., Darrah, S. F., Tekabe, Y., Perlstein, A., Wax, R., Bruck, E., Stauber, J., Corbin, K. A., Buchen, C., Slavkovich, V., Graziano, J., Spitalnik, S. L., … Qiu, A. Disposal of iron by a mutant form of lipocalin 2. Nature Communications, 2016, 7, 1–12. DOI: 10.1038/ncomms12973. Link
  3. Abergel, R. J. Chapter 6: Chelation of actinides. In Metal Chelation in Medicine (pp. 183–212). DOI: 10.1039/9781782623892-00183. Link
  4. Deblonde, G. J.-P., & Abergel, R. J. Active actinium. Nature Chemistry, 2016, 8, 1084–1084. DOI: 10.1038/nchem.2653. Link
  5. Dau, P. D., Shuh, D. K., Sturzbecher-Hoehne, M., Abergel, R. J., & Gibson, J. K. Divalent and trivalent gas-phase coordination complexes of californium: Evaluating the stability of Cf(II). Dalton Trans., 2016, 45, 12338–12345. DOI: 10.1039/C6DT02414A. Link
  6. Agbo, P., & Abergel, R. J. Ligand-sensitized lanthanide nanocrystals: Merging solid-state photophysics and molecular solution chemistry. Inorg. Chem. 2016, 55, 9973–9980. DOI: 10.1021/acs.inorgchem.6b00879. Link
  7. Abergel, R. J., & Ansoborlo, E. Curious curium. Nature Chemistry, 2016, 8, 516–516. DOI: 10.1038/nchem.2512. Link
  8. Agbo, P., Xu, T., Sturzbecher-Hoehne, M., & Abergel, R. J. Enhanced ultraviolet photon capture in ligand-sensitized nanocrystals. ACS Photonics, 2016, 3, 547–552. DOI: 10.1021/acsphotonics.6b00118. Link
  9. Sturzbecher-Hoehne, M., Yang, P., D’Aléo, A., & Abergel, R. J. Intramolecular sensitization of americium luminescence in solution: Shining light on short-lived forbidden 5f transitions. Dalton Trans., 2016, 45, 9912–9919. DOI: 10.1039/C6DT00328A. Link
  10. Kamada, K., Namikawa, T., Senatore, S., Matthews, C., Lenne, P.-F., Maury, O., Andraud, C., Ponce-Vargas, M., Le Guennic, B., Jacquemin, D., Agbo, P., An, D. D., Gauny, S. S., Liu, X., Abergel, R. J., Fages, F., & D’Aléo, A. Boron difluoride curcuminoid fluorophores with enhanced two-photon excited fluorescence emission and versatile living-cell imaging properties. Chemistry – Eur. J., 2016, 22, 5219–5232. DOI: 10.1002/chem.201504903. Link

2015

  1. Allred, B. E., Rupert, P. B., Gauny, S. S., An, D. D., Ralston, C. Y., Sturzbecher-Hoehne, M., Strong, R. K., & Abergel, R. J. Siderocalin-mediated recognition, sensitization, and cellular uptake of actinides.  Proc. Natl. Acad. Sci. U.S.A. , 2015, 112, 10342–10347. DOI: 10.1073/pnas.1508902112. Link
  2. Choi, T. A., Endsley, A. N., Bunin, D. I., Colas, C., An, D. D., Morales‐Rivera, J. A., Villalobos, J. A., Shinn, W. M., Dabbs, J. E., Chang, P. Y., & Abergel, R. J. Biodistribution of the multidentate hydroxypyridinonate ligand [14C]-3,4,3-LI(1,2-HOPO), a potent actinide decorporation agent. Drug Development Research, 2015, 76, 107–122. DOI: 10.1002/ddr.21246. Link
  3. Sturzbecher-Hoehne, M., Choi, T. A., & Abergel, R. J. Hydroxypyridinonate complex stability of group (IV) metals and tetravalent f-block elements: The key to the next generation of chelating agents for radiopharmaceuticals. Inorg. Chem. 2015, 54, 3462–3468. DOI: 10.1021/acs.inorgchem.5b00033. Link
  4. Choi, T. A., Furimsky, A. M., Swezey, R., Bunin, D. I., Byrge, P., Iyer, L. V., Chang, P. Y., & Abergel, R. J. In vitro metabolism and stability of the actinide chelating agent 3,4,3-LI(1,2-HOPO). Journal of Pharmaceutical Sciences, 2015, 104, 1832–1838. DOI: 10.1002/jps.24394. Link
  5. Choi, T. A., Costes, S. V., & Abergel, R. J. Understanding the health impacts and risks of exposure to radiation. In J. Ahn, C. Carson, M. Jensen, K. Juraku, S. Nagasaki, & S. Tanaka (Eds.), Reflections on the Fukushima Daiichi Nuclear Accident: Toward Social-Scientific Literacy and Engineering Resilience (pp. 259–281). Springer International Publishing. DOI: 10.1007/978-3-319-12090-4_13. Link
  6. Liu, M., Wang, J., Wu, X., Wang, E., Abergel, R. J., Shuh, D. K., Raymond, K. N., & Liu, P. Characterization, HPLC method development and impurity identification for 3,4,3-LI(1,2-HOPO), a potent actinide chelator for radionuclide decorporation. Journal of Pharmaceutical and Biomedical Analysis, 2015, 102, 443–449. DOI: 10.1016/j.jpba.2014.10.015. Link

2014

  1. Abergel RJ. Les futurs agents chélatants sont déjà là. Biofutur. 2014, 353, 47-51. Link
  2. Panyala, N. R., Sturzbecher-Hoehne, M., & Abergel, R. J. Identification of process related trace level impurities in the actinide decorporation agent 3,4,3-LI(1,2-HOPO): Nozzle–skimmer fragmentation via ESI LC–QTOFMS. Journal of Pharmaceutical and Biomedical Analysis, 2014, 100, 157–166. DOI: 10.1016/j.jpba.2014.08.004. Link
  3. An, D. D., Villalobos, J. A., Morales-Rivera, J. A., Rosen, C. J., Bjornstad, K. A., Gauny, S. S., Choi, T. A., Sturzbecher-Hoehne, M., & Abergel, R. J. 238Pu elimination profiles after delayed treatment with 3,4,3LI(1,2HOPO) in female and male Swiss-Webster mice. International Journal of Radiation Biology, 2014, 90, 1055–1061. DOI: 10.3109/09553002.2014.925150. Link
  4. Sturzbecher-Hoehne, M., Kullgren, B., Jarvis, E. E., An, D. D., & Abergel, R. J. Highly luminescent and stable hydroxypyridinonate complexes: A step towards new curium decontamination strategies. Chemistry – Eur. J., 2017, 20, 9962–9968. DOI: 10.1002/chem.201402103 . Link

2013

  1. Deblonde, G. J.-P., Sturzbecher-Hoehne, M., & Abergel, R. J. Solution thermodynamic stability of complexes formed with the octadentate hydroxypyridinonate ligand 3,4,3-LI(1,2-HOPO): A critical feature for efficient chelation of lanthanide(IV) and actinide(IV) ions. Inorg. Chem. 2013, 52, 8805–8811. DOI: 10.1021/ic4010246. Link
  2. Sturzbecher-Hoehne, M., Deblonde, G. J.-P., & Abergel, R. J. Solution thermodynamic evaluation of hydroxypyridinonate chelators 3,4,3-LI(1,2-HOPO) and 5-LIO(Me-3,2-HOPO) for UO2(VI) and Th(IV) decorporation. Radiochimica Acta, 2013, 101, 359–366. DOI: 10.1524/ract.2013.2047. Link
  3. Deblonde, G. J.-P., Sturzbecher-Hoehne, M., Mason, A. B., & Abergel, R. J. Receptor recognition of transferrin bound to lanthanides and actinides: A discriminating step in cellular acquisition of f-block metals. Metallomics, 2013, 5, 619–626. DOI: 10.1039/C3MT20237B. Link
  4. Bunin, D. I., Chang, P. Y., Doppalapudi, R. S., Riccio, E. S., An, D., Jarvis, E. E., Kullgren, B., & Abergel, R. J. Dose-dependent efficacy and safety toxicology of hydroxypyridinonate actinide decorporation agents in rodents: Towards a safe and effective human dosing regimen. Radiation Research, 2013, 179, 171–182. DOI: 10.1667/RR3115.1. Link
  5. Sturzbecher-Hoehne, M., Goujon, C., Deblonde, G. J.-P., Mason, A. B., & Abergel, R. J. Sensitizing curium luminescence through an antenna protein to investigate biological actinide transport mechanisms. J. Am. Chem. Soc., 2013, 135, 2676–2683. DOI: 10.1021/ja310957f. Link

2012

  1. Jarvis, E. E., An, D. D., Kullgren, B., Abergel, R. J. Significance of Single Variables in Defining Adequate Animal Models to Assess the Efficacy of New Radionuclide Decorporation Agents: Using the Contamination Dose as an Example. Drug Dev. Res. 2012, 73, 281-289. DOI: 10.1002/ddr.21020. Link

2011

  1. Correnti, C., Clifton, M. C., Abergel, R. J., Allred, B., Hoette, T. M., Ruiz, M., Cancedda, R., Raymond, K. N., Descalzi, F., & Strong, R. K. Galline ex-fabp is an antibacterial siderocalin and a lysophosphatidic acid sensor functioning through dual ligand specificities. Structure, 2011, 19, 1796–1806. DOI: 10.1016/j.str.2011.09.019. Link
  2. Abergel, R. J., & Raymond, K. N. Multidentate terephthalamidate and hydroxypyridonate ligands: Towards new orally active chelators. Hemoglobin, 2011, 35, 276–290. DOI: 10.3109/03630269.2011.560771. Link
  3. Chang, P. Y., Bunin, D. I., Gow, J., Swezey, R., Shinn, W., Shuh, D. K., & Abergel, R. J. Analytical methods for the bioavailability evaluation of hydroxypyridinonate actinide decorporation agents in pre-clinical pharmacokinetic studies. Journal of Chromatography & Separation Techniques, 2011, 4, 1–6. DOI: 10.4172/2157-7064.1000196. Link
  4. Sturzbecher-Hoehne, M., Leung, C. N. P., D’Aléo, A., Kullgren, B., Prigent, A.-L., Shuh, D. K., Raymond, K. N., & Abergel, R. J. 3,4,3-LI(1,2-HOPO): In vitro formation of highly stable lanthanide complexes translates into efficacious in vivo europium decorporation. Dalton Trans. 2011, 40, 8340–8346. DOI: 10.1039/C1DT10840A. Link

2010

  1. Abergel, R. J., Durbin, P. W., Kullgren, B., Ebbe, S. N., Xu, J., Chang, P. Y., Bunin, D. I., Blakely, E. A., Bjornstad, K. A., Rosen, C. J., Shuh, D. K., & Raymond, K. N. Biomimetic actinide chelators: An update on the preclinical development of the orally active hydroxypyridonate decorporation agents 3,4,3-LI(1,2-HOPO) and 5-LIO(Me-3,2-HOPO). Health Physics, 2010, 99, 401–407. DOI: 10.1097/HP.0b013e3181c21273. Link

Past

  1. Wilson, M. K., Abergel, R. J., Arceneaux, J. E. L., Raymond, K. N., Byers, B. R. Temporal production of the two Bacillus anthracis siderophores, petrobactin and bacillibactin. BioMetals, 2010, 23, 129, 134. DOI: 10.1007/s10534-009-9272-x. Link
  2. Abergel, R. J., D’Aleo, A., Ng Pak Leung, C., Shuh, D. K., Raymond, K. N. Using the Antenna Effect as a Spectroscopic Tool: Photophysics and Solution Thermodynamics of the Model Luminescent Hydroxypyridonate Complex [EuIII(3,4,3-LI(1,2-HOPO))]−. Inorg. Chem. 2009, 48, 10868–10870. DOI: 10.1021/ic9013703. Link
  3. Abergel, R. J., Zawadzka, A. M., Hoette, T. M., Raymond, K. N. Enzymatic Hydrolysis of Trilactone Siderophores: Where Chiral Recognition Occurs in Enterobactin and Bacillibactin Iron Transport. J. Am. Chem. Soc. 2009, 131, 12682–12692. DOI: 10.1021/ja903051q. Link
  4. Zawadzka, A. M., Abergel, R. J., Nichiporuk, R., Andersen, U. N., Raymond, K. N. Siderophore-Mediated Iron Acquisition Systems in Bacillus cereus: Identification of Receptors for Anthrax Virulence-Associated Petrobactin. Biochemistry, 2009, 48, 3645–3657. DOI: 10.1021/bi8018674. Link
  5. Hoette, T. M., Abergel, R. J., Xu, J., Strong, R. K., Raymond, K. N. The Role of Electrostatics in Siderophore Recognition by the Immunoprotein Siderocalin. J. Am. Chem. Soc. 2008, 130, 17584–17592. DOI: 10.1021/ja8074665. Link
  6. Abergel, R. J., Clifton, M. C., Pizarro, J. C. Warner, J. A., Shuh, D. K., Strong, R. K. Raymond, K. N. The Siderocalin/Enterobactin Interaction: A Link between Mammalian Immunity and Bacterial Iron Transport. J. Am. Chem. Soc. 2008, 130, 11524-11534. DOI: 10.1021/ja803524w. Link
  7. Abergel. R. J., Zawadzka, A. M., Raymond, K. N. Petrobactin-Mediated Iron Transport in Pathogenic Bacteria:  Coordination Chemistry of an Unusual 3,4-Catecholate/Citrate Siderophore. J. Am. Chem. Soc. 2008, 130, 2124-2125. DOI: 10.1021/ja077202g. Link
  8. Abergel. R. J., Raymond, K. N. Terephthalamide-containing ligands: fast removal of iron from transferrin. JBIC Journal of Biological Inorganic Chemistry, 2008, 13, 229-240. DOI: 10.1007/s00775-007-0314-y. Link
  9. Abergel, R. J., Wilson, M. K., Arceneaux, J. E. L., Hoette, T. M., Strong, R. K., Byers, B. R., Raymond, K. N. Anthrax pathogen evades the mammalian immune system through stealth siderophore production.  Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 18499-18503. DOI: 10.1073/pnas.0607055103. Link
  10. Fischbach, M. A., Lin, H., Zhou, L., Yu, Y., Abergel, R. J., Liu, D. R., Raymond, K. N., Wanner, B. L., Strong, R. K., Walsh, C. T., Aderem, A., Smith, K. D. The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2.  Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 16502-16507. DOI: 10.1073/pnas.0604636103. Link
  11. Wilson, M. K., Abergel, R. J., Raymond, K. N. Arceneaux, J. E. L., Byers, B. R. Siderophores of Bacillus anthracis, Bacillus cereus, and Bacillus thuringiensis. Biochemical and Biophysical Research Communication, 2006, 348, 320-325. DOI: 10.1016/j.bbrc.2006.07.055. Link
  12. Abergel. R. J., Moore, E. G., Strong, R. K., Raymond, K. N. Microbial Evasion of the Immune System:  Structural Modifications of Enterobactin Impair Siderocalin Recognition. J. Am. Chem. Soc. 2006, 128, 10998–10999. DOI: 10.1021/ja062476+. Link
  13. Abergel. R. J., Warner, J. A., Shuh, D. K., Raymond, K. N., Enterobactin Protonation and Iron Release:  Structural Characterization of the Salicylate Coordination Shift in Ferric Enterobactin. J. Am. Chem. Soc. 2006, 128, 8920–8931. DOI: 10.1021/ja062046j. Link
  14. Abergel. R. J., Raymond, K. N. Synthesis and Thermodynamic Evaluation of Mixed Hexadentate Linear Iron Chelators Containing Hydroxypyridinone and Terephthalamide Units. Inorg. Chem. 2006, 45, 9, 3622–363. DOI: 10.1021/ic052111a. Link